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Once absorbed, glucosinolate-derived isothiocyanates (like sulforaphane) are promptly conjugated to glutathione by a class of phase II detoxification enzymes known as glutathione S -transferases (GSTs) in the liver, and then sequentially metabolized in the mercapturic acid pathway ( Figure 2 )

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Patients undergoing certain chemotherapeutic agentssuch as methotrexate or platinum-based drugsshould consult closely with both their oncologist and naturopathic provider, as timing and dosing of nutrients may influence drug efficacy